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Fine and UFPs directly stimulate macrophages and epithelial cells to produce inflammatory cytokines such as TNF-, TGF-1, GM-CSF, PDGF, IL-6, and IL-8 72 , and reactive oxygen species are responsible for acute and chronic lung inflammation 73

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Finally, to further assess immunogenicity, NetMHC4.1 was used to predict T-cell epitopes and IEDB analysis was used to predict antibody epitopes, in which the REW amino acid substitutions did not significantly increase the number of potentially immunogenic peptides or epitopes compared with WT IgG1 and other Fc-engineering strategies for half-life modulation (Tables S11S12)

Muller, Eric L